Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- - Names and Identifiers
Name | 1,8-Diazabicyclo[5.4.0]undec-7-ene
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Synonyms | DBU Diazabicycloundecene 1,5-Diaza(5,4,0)undec-5-ene 1,8-Diazabicyclo(5,4,0)undec-7-ene 1,8-Diazabicyclo[5.4.0]undec-7-ene 1,8-diazabicyclo(5.4.0)undec-7-ene 1,5-Diazabicyclo[5.4.0]-5-undecene 1,5-DIAZABICYCLO[5.4.0]UNDEC-5-ENE 1,8-diazabicyclo (5.4.0) undec-7-ene Dicyclo[5,4,0]-1,8-Diazole-7-Nonylene 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine 2-a]azepine,2,3,4,6,7,8,9,10-octahydro-pyrimido[ 2-a]azepine,2,3,4,6,7,8,9,10-octahydro-Pyrimido[1 Pyrimido[1,2-a]azepine,2,3,4,6,7,8,9,10-octahydro- Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- 2,3,4,6,7,8,9,10-Octahydropyrimido(1,2-alpha)azepine 2,3,4,6,7,8,9,10-octahydro-1H-pyrimido[1,2-a]azepin-5-ium
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CAS | 6674-22-2
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EINECS | 229-713-7 |
InChI | InChI=1/C9H16N2/c1-2-5-9-10-6-4-8-11(9)7-3-1/h1-8H2/p+1 |
Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- - Physico-chemical Properties
Molecular Formula | C9H17N2
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Molar Mass | 153.244 |
Melting Point | -70℃ |
Boling Point | 274.6°C at 760 mmHg |
Flash Point | 119.9°C |
Water Solubility | soluble |
Vapor Presure | 0.00536mmHg at 25°C |
Physical and Chemical Properties | Melting Point -70°C boiling point 80-83°C C 0.6mm Hg(lit.)
density 1.019g/mL at 20°C(lit.)
vapor pressure 5.3mm Hg (37.7°C)
refractive index n20/D 1.523
flash point> 230 °F
storage conditions Store at R.T. solubility soluble water-soluble solution Sensitive Air BRN 508906
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Use | It is used in the manufacture of cephalosporin semi-synthetic antibiotic drugs, and also used in the preparation of deacidification agents, rust inhibitors, advanced corrosion inhibitors, etc. |
Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- - Risk and Safety
Hazard Symbols | C - Corrosive
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Risk Codes | R22 - Harmful if swallowed
R35 - Causes severe burns
R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
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UN IDs | UN 3267 |
Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- - Introduction
Open Data Unverified Data
1,8-Diazabicyclo[5.4.0]undec-7-ene, often referred to as 1,8-Diazabicyclo[5.4.0]undec-7-ene or simply DBU, is an important organic compound. Its nature is as follows:
1. appearance and properties: DBU is a colorless, transparent liquid. It has a strong ammonia smell and strong hygroscopicity.
2. Solubility: DBU is soluble in many common organic solvents, such as ethanol, ether, chloroform and dimethylformamide.
3. Stability: DBU is stable and can be stored for a long time at room temperature.
4. combustion: DBU is flammable, pay attention to avoid contact with the fire source.
DBU has a wide range of applications:
1. Catalyst: DBU is a strong base, commonly used as a base catalyst in organic synthesis, especially in condensation reactions, substitution reactions and cyclization reactions.
2. Ion exchanger: DBU can form salts with organic acids and is used as an anion exchanger. It is often used in organic synthesis and analytical chemistry.
3. Chemical reagent: DBU is commonly used in hydrogenation reaction, deprotection reaction and strong base catalyzed amine substitution reaction in organic synthesis.
The method of preparing DBU is as follows:
In general, the synthesis of DBU can be obtained by the reaction of 2-dehydropiperidine with ammonia. The specific synthesis method is cumbersome and usually requires an organic synthesis laboratory.
Safety information about the DBU:
1. DBU is highly corrosive and may cause irritation to skin and eyes. Wear protective gloves and goggles during use to avoid direct contact.
2. When storing and using DBU, a well-ventilated environment should be maintained to reduce the concentration of odors and vapors.
3. avoid reaction with oxidant, acid and organic matter, and avoid operation near the fire source.
4. When disposing of waste, please follow local regulations and safe operating procedures.
It is important that when using and handling DBU, please carefully read and follow the relevant safety guidelines and operating procedures.
Last Update:2024-04-10 11:20:06